Changing Channels

HHMI Bulletin | February 2012

Scott Sternson has always wondered what drives behavior, especially those fundamental motivations required for survival. Hunger, for example, is so crucial that it must be evolutionarily “hard-wired” deep within the brain. After all, as Sternson observes, “if the animal doesn’t eat, it dies.” read story

Outsmarting the Toughest Bacteria

HHMI Bulletin | August 2007

Superbugs, the disease-causing bacteria that are resistant to even the most high-powered antibiotics, are becoming more commonplace.  One dangerous strain called methicillin-resistant Staphylococcus aureus (MRSA), once restricted to hospital wards, is turning up in soccer fields and gym lockers.  read in full issue (pdf)

Protein Disposal: Gumming Up the Works

HHMI Bulletin | September 2005

For a cell, destroying proteins is as essential as building them. The job of mincing proteins is performed by enzymatic machines called proteasomes. “Proteasomes affect almost all biological processes in the cell,” Verma says. By their deliberate destruction of regulatory proteins, they orchestrate activities from cell division to cell death. read in full issue (pdf)

We Get a Kick from Kinesins

HHMI Bulletin | December 2005

At a recent seminar, HHMI investigator Larry Goldstein flashed a slide of Godzilla, the monster of Japanese sci-fi, towering over a cityscape, devouring a string of railroad cars. The next slide showed Arnold Schwarzenegger as Conan the Barbarian, bedecked in fur loincloth and sword, muscles bulging.  read in full issue (pdf)

Sidebar:  Conducting the Choir